Effect of Dengue Fever on Liver Enzymes
DOI:
https://doi.org/10.71395/ijhp.1.2.2024.52-56Abstract
Background and Objectives: Dengue fever is a disease that is commonly found in endemic areas and is caused by the dengue virus which is spread by mosquitoes, specifically the Aedes aegypti mosquito. To determine the platelet count in dengue fever patients on the 5th day of diagnosis. To determine the correlation of dengue fever with liver enzyme.
METHODOLOGY: A retrospective study was conducted in the Bahria Hospital in Lahore, Pakistan. The study was conducted during the 3 months from May to July, 2023. The study included a total of 140 individuals with confirmed dengue fever, comprising 58 women and 82 men with ages ranging from 1 to 90. The study was conducted to determine the platelet count on the 5th day of diagnosis and to find out the correlation of dengue fever with liver enzymes. Patients were dived into 3 groups according to the age range 5-30, 31-60, and 61-90 years. Hematology results of these patients indicated low platelet count (<130×109/L). The instrument or machines we used for platelet count and liver enzyme measurement were Cell-DYN Ruby and Alinity ci-series respectively. A self-designed Performa was used to collect the patient data. Data were entered and analyzed by using excel and displayed by using Tables and Bar Charts.
RESULTS: According to the study, adults between the ages of 31 and 60 were most frequently affected by low platelet counts. Aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP) levels were also found to be increased in individuals between the ages of 5 and 30 in 26%, 27%, and 8.5% of instances, respectively. The majority of patients with higher AST, ALT, and ALP values were between the ages of 31 and 60, with 53.5%, 52%, and 15.7% of patients displaying increased levels, respectively. In 14%, 14%, and 3.7% of patients between 61 and 90 years old, respectively, increased levels of AST, ALT, and ALP were found.
CONCLUSION: In conclusion, patients between the ages of 31 and 60 were found to have the highest prevalence of increased aminotransferases among all age categories, with AST and ALT levels being twice as high as ALP levels.
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