Frequency of Anti-Thyroid Peroxidase (Anti-TPO) in Diabetes Mellitus Type 1 Patients
DOI:
https://doi.org/10.71395/ijhp.1.3.2024.8-12Abstract
Background and Objectives: The association between autoimmune thyroiditis and diabetes mellitus type 1 is of great significance, as both are autoimmune disorders. The presence of one autoimmune disorder increases the risk of developing another autoimmune disorder. To determine the frequency of anti-thyroid peroxidase (anti-TPO) antibodies in individuals diagnosed with diabetes mellitus type 1. On the basis of gender, age and among the diagnosed patients of hypothyroidism and hyperthyroidism with diabetes mellitus type 1.
METHODOLOGY: A retrospective study was conducted in University of Lahore Teaching Hospital, Lahore, Punjab. The study was conducted during the 3 months from May to July, 2023. The research involved examining of 135 diabetes type 1 patients, with an average age of 27.44 years, comprising 60 males (44.44%) and 75 females
(55.56%) with different age groups. Cobas C-311 and Enzyme-linked Immunosorbent assay (ELISA) were used to analyze glycosylated hemoglobin (HbA1c) and anti-thyroid peroxidase antibodies (anti-TPO) respectively. A self-designed Performa was used to collect the patient data. Data were entered and analyzed by using excel and
displayed by using Tables and Bar Charts.
RESULTS: Anti-TPO antibodies were detected in 25 patients (18.52%) out of the 135 participants, although they were absent in 110 patients (81.48%). Notably, females (76%) were more likely to have anti-TPO antibodies than men (24%), especially in those between the ages of 10 and 25 (64%). Only one of the 135 people had anti-TPO antibodies, despite the fact that five of them had hypothyroidism. Three of the 135 patients were diagnosed cases of hyperthyroidism, and all three were anti-TPO negative.
CONCLUSION: The conclusion of this study is that anti-TPO antibodies are very common in diabetes mellitus type 1 patients and gender and age have a significant impact on the formation of anti-TPO antibodies.
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